CONOLIDINE ALKALOID FOR CHRONIC PAIN NO FURTHER A MYSTERY

Most lately, it has been discovered that conolidine and the above derivatives act over the atypical chemokine receptor three (ACKR3. Expressed in related regions as classical opioid receptors, it binds to the big range of endogenous opioids. Not like most opioid receptors, this receptor acts for a scavenger and does not activate a second messenger